Persistent gastroesophageal reflux disease symptoms on standard proton-pump inhibitor therapy

Eight patients with refractory GERD symptoms were controlled over a mean of 15.4 years only by the addition of a benzodiazepine to once-daily or twice-daily PPI therapy. In selected patients with refractory GERD, as defined by continued reflux symptoms despite twice-daily PPIs, the addition of a benzodiazepine to the PPI regimen may provide additional control of GERD symptoms.