Related Experiment Videos
Preparing functional bis(indole) pyrazine by stepwise cross-coupling reactions: an efficient method to construct the
Cai-Guang Yang1, Gang Liu, Biao Jiang
1Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, P. R. China.
The Journal of Organic Chemistry
|December 21, 2002
Abstract:
A direct approach for selective construction of properly substituted bis(indole) pyrazine, the skeleton of a marine alkaloid dragmacidin D, has been developed. The key steps involved the regioselective introduction of two indole units, using the palladium(0)-catalyzed Suzuki and the Stille cross-coupling reactions sequentially.