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Synthesis of C-3' methyl taxotere (docetaxel)
Christophe Lucatelli1, Florian Viton, Yves Gimbert
1LEDSS, Université Joseph Fourier, Chimie Recherche, BP 53X, 38041 Grenoble Cedex, France.
The Journal of Organic Chemistry
|December 21, 2002
Abstract:
Protected (3R,4S)-N-Boc-3-hydroxy-4-methyl-4-phenylazetidin-2-one has been synthesized stereoselectively and used to esterify protected 10-desacetylbaccatin III to give, following removal of the protecting groups, novel C-3' methyl taxotere (docetaxel).