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Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection
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Single-Cell Multiplexed Fluorescence Imaging to Visualize Viral Nucleic Acids and Proteins and Monitor HIV, HTLV, HBV, HCV, Zika Virus, and Influenza Infection

Published on: October 29, 2020

HIV-1, hepatitis B virus, and risk of liver-related mortality in the Multicenter Cohort Study (MACS)

Chloe L Thio1, Eric C Seaberg, Richard Skolasky

  • 1Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA. cthio@jhmi.edu

Lancet (London, England)
|December 21, 2002
PubMed

Insights

Coinfection with HIV-1 and hepatitis B virus (HBV) significantly increases liver-related mortality, particularly in individuals with lower CD4+ counts. Comprehensive hepatitis B management is crucial for those with HIV-1.

Area of Science:

  • Hepatology
  • Infectious Diseases
  • Public Health

Background:

  • Coinfection with Human Immunodeficiency Virus type 1 (HIV-1) and Hepatitis B Virus (HBV) is prevalent.
  • Long-term data on liver disease mortality in coinfected individuals are scarce.
  • This study aimed to assess liver-related mortality in a cohort at risk for HIV-1 and HBV infections.

Purpose of the Study:

  • To investigate the impact of HIV-1 and HBV coinfection on liver-related mortality.
  • To identify risk factors associated with increased liver mortality in coinfected individuals.

Main Methods:

  • A multicenter, prospective cohort study of 5293 men who have sex with men.
  • Classification based on HIV-1 antibody status and Hepatitis B surface antigen (HBsAg) status.
  • Mortality rates estimated using person-years and Poisson regression.

Main Results:

  • Liver-related mortality rate was 1.1 per 1000 person-years.
  • Mortality was significantly higher in individuals coinfected with HIV-1 and HBsAg (14.2/1000) compared to those with single infections.
  • Higher mortality rates were observed in coinfected individuals with lower nadir CD4+ cell counts and after the introduction of highly active antiretroviral therapy (HAART).

Conclusions:

  • HIV-1 and HBV coinfection poses a substantial risk for liver-related mortality.
  • Low CD4+ nadir counts are associated with increased mortality in coinfected individuals.
  • Emphasizes the need for prevention, early detection, and integrated management of Hepatitis B in HIV-1-infected populations.
Abstract

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