[Use of selective long-acting beta-blocker with vasodilating activity celiprolol in patients with essential...

Effects of 8 weeks therapy with long-acting selective b-blocker celiprolol (200 mg o.d.) on 24-hour blood pressure, central hemodynamics (oscillometry) and microcirculation (laser doppler flowmetry) were studied in 30 patients (17 women and 13 men, mean age 51.9 years), with stage I-II essential hypertension. Celiprolol lowered both systolic and diastolic blood pressure (BP) during all periods of 24-hour BP monitoring and improved BP circadian rhythm. Treatment with celiprolol was not associated with considerable heart rate decrease or changes of stroke volume and cardiac output. 24 hour monitoring of parameters of central hemodynamics during treatment with celiprolol revealed existence of significant direct correlation between mean BP and total peripheral vascular resistance. Thus, hypotensive effect of celiprolol was mostly attributed to its vasodilatory action. This activity of celiprolol was confirmed by its beneficial influence on parameters of microcirculation. After therapy normalization of peripheral blood flow was observed in 50%, and tendency to its improvement--in 83,3 % of patients.