Related Experiment Video

Updated: Sep 28, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

[Blood lipids in offsprings of patients with ischemic heart disease]

T P Novgorodtseva, N S Zhuravskaia, O G Vostrikova

    Kardiologiia
    |December 21, 2002
    PubMed

    Insights

    Family members share similar lipid metabolism traits, influencing ischemic heart disease risk. Three distinct patterns of lipid metabolism disturbances were identified across generations, highlighting familial patterns in cardiovascular health.

    Area of Science:

    • Cardiovascular Medicine
    • Metabolic Disorders
    • Genetics

    Context:

    • Ischemic heart disease (IHD) has a significant familial component.
    • Understanding lipid metabolism variations across generations is crucial for IHD risk assessment.
    • Previous studies have explored genetic and environmental factors in IHD, but familial lipid profiles require further elucidation.

    Purpose:

    • To investigate the correlations between lipid metabolism characteristics in patients with ischemic heart disease (IHD) and their offspring.
    • To identify distinct familial patterns of lipid metabolism disturbances.

    Summary:

    • This study analyzed lipid levels, lipoprotein profiles, apolipoproteins, erythrocyte phospholipid and fatty acid composition, and intracellular cholesterol in smooth muscle cells from IHD patients (probands) and their first and second-generation offspring.
    • Family members exhibited similar lipid metabolism characteristics.
    • Three distinct variants of familial lipid metabolism disturbances were identified based on lipid levels, erythrocyte composition, and serum atherogenic factors.

    Impact:

    • Identifies specific familial lipid metabolism patterns associated with IHD.
    • Provides insights into the heritability of dyslipidemia and cardiovascular risk.
    • May inform targeted screening and prevention strategies for families with a history of IHD.
    Abstract

    Related Concept Videos

    Blood Studies for Cardiovascular System III: Serum Lipid Profile01:25

    Blood Studies for Cardiovascular System III: Serum Lipid Profile

    Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
    Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
    Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...
    Lipids: Dietary Sources and Requirements01:18

    Lipids: Dietary Sources and Requirements

    Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...
    Lipid-Lowering Drugs: Statins and Miscellaneous Agents01:20

    Lipid-Lowering Drugs: Statins and Miscellaneous Agents

    Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...
    Lipid-derived Compounds in the Human Body01:31

    Lipid-derived Compounds in the Human Body

    Fats and lipids are crucial components in the human body. Some lipid-derived compounds, such as fat-soluble vitamins, eicosanoids, lipoproteins, and glycolipids, also play unique roles to support various  biological processes .
    Fat-soluble Vitamins
    Fat-soluble vitamins, including vitamins A, D, E, and K, are required in minimal quantities, but their deficiencies can lead to severely abnormal physiological conditions. For example, vitamin A deficiency can cause night blindness, dry skin, delayed...
    Cholesterol: Significance and Regulation01:29

    Cholesterol: Significance and Regulation

    Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
    Considering cholesterol and...
    Structure of Lipids03:38

    Structure of Lipids

    Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic birds and...