[Comparative assessment of different types of adaptational protection of the myocardium during stress]

To study in rats effects of 3 types of adaptation on structural rearrangement of myocardium during stress.

Corrosion preparations of coronary vessels, morphometry of focal lesions of cardiomyocytes and correlation analysis of relationships between data obtained by these methods.

Preliminary adaptation to mild stress exerted maximal protection of myocardial cells against severe stress at minimal expansion of coronary vascular bed. Correlation analysis showed that vascular factor played modest role in realization of this cardioprotection (Pearson coefficient 0.31, p<0.05). On the contrary adaptation to hypoxia exerted minimal protective effect on myocardium against stress despite maximal expansion of vascular bed. The latter factor played rather important role in realization of this type of cardioprotection (correlation coefficient -0.89, p<0.001). Adaptation to physical effort occupied intermediate position according to the parameters studied.