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IgA nephropathy in a patient with chronic granulomatous disease
Sriram S Narsipur1, Paul F Shanley
1Department of Medicine, State University of New York, Upstate Medical University, Syracuse, New York 13210, USA. narsipur@upstate.edu
Journal of Nephrology
|December 24, 2002
Abstract:
We report the first documented case of X-linked chronic granulomatous disease (CGD) in association with IgA nephropathy in a 22 year old male with multiple soft tissue abscesses. The case highlights the potential role of staphylococcal infections in the pathogenesis of IgA nephropathy and suggests the hypothesis that the neutrophil defect in CGD predisposes to such infections which may trigger IgA immune complex formation.