Related Experiment Videos
Effect of prolonged hyperdynamic endotoxemia on jejunal motility in fasted and enterally fed pigs
Maaike J Bruins1, Yvette C Luiking, Peter B Soeters
1Department of Surgery, Maastricht University, Maastricht, The Netherlands. m.bruins@chem.leidenuniv.nl
Objective:
To determine the effects of hyperdynamic endotoxemia on the motility of the small intestine.
Summary Background Data:
Motility disorders of the gastrointestinal tract are a common complication of sepsis. It has been suggested that gram-negative endotoxin plays a role in the pathogenesis of the accompanying diarrhea frequently observed.
Methods:
Pigs were infused with lipopolysaccharide for a 24-hour period. During this fasting period jejunal motility was measured using ambulatory manometry. One and 4 days after cessation of endotoxin, pigs were enterally fed, and again motility was recorded.
Results:
Hyperdynamic endotoxemia was achieved in this model. Manometric pressure recordings revealed that endotoxin infusion accelerated the migrating motor complex (MMC) migration along the jejunum. Also, a simultaneous increase in MMC cycling frequency was observed in the endotoxin-treated group. Elevated MMC migration velocity and cycling frequency were maintained the following day after endotoxin during feeding and returned to basal values 4 days after endotoxin.
Conclusions:
A small dose of continuously infused endotoxin significantly provokes jejunal motility disturbances that may contribute to diarrhea.