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Related Experiment Videos

Microvessel density in prostate carcinoma.

A V Bono1, N Celato, V Cova

  • 1Division of Urology, Ospedale di Circolo e Fondazione Macchi, Varese, Italy.

Prostate Cancer and Prostatic Diseases
|December 24, 2002
PubMed
Summary

Microvessel density (MVD) in prostate cancer correlates with pathological stage and recurrence. Higher MVD indicates increased risk of disease progression after radical prostatectomy, aiding outcome prediction.

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Area of Science:

  • Oncology
  • Pathology
  • Urology

Background:

  • Prostate cancer recurrence after radical prostatectomy is a significant clinical concern.
  • Predictive markers for disease progression are crucial for patient management.

Purpose of the Study:

  • To assess the correlation between microvessel density (MVD), pathological stage, and disease recurrence in prostate cancer patients.
  • To evaluate the predictive value of MVD for outcomes following radical prostatectomy.

Main Methods:

  • Re-examination of pathological material from 75 radical prostatectomies.
  • Identification of maximal angiogenesis areas and CD34 expression.
  • Counting CD34+ microvessels, categorizing into MVD<90 and MVD>90 groups.

Main Results:

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  • Microvessel density (MVD) positively associated with higher pathological stage and Gleason score.
  • Disease progression observed in 20% of MVD<90 patients vs. 51% of MVD>90 patients (P=0.006).
  • Significant correlation found between MVD and time to disease progression (P<0.05).

Conclusions:

  • Microvessel density, assessed by CD34 staining, is a significant predictor of outcome in prostate cancer.
  • Elevated MVD correlates with advanced pathological stage and increased risk of recurrence.
  • MVD measurement offers a valuable tool for predicting post-prostatectomy disease progression.