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Updated: Aug 11, 2026
06:54
MR Molecular Imaging of Prostate Cancer with a Small Molecular CLT1 Peptide Targeted Contrast Agent
Published on: September 3, 2013
Imaging with prostate-specific membrane antigen (PSMA) in prostate cancer
M R Feneley1, H Jan, M Granowska
1Department of Urology, Royal Hospitals NHS Trust, London, UK.
Prostate Cancer and Prostatic Diseases
|December 24, 2002
Summary
Radioimmunoscintigraphy using prostate-specific membrane antigen (PSMA) antibodies effectively images prostate cancer, including lymph nodes and metastases. This functional imaging aids clinical management decisions for localized, recurrent, and rising PSA cases.
Area of Science:
- Nuclear Medicine
- Oncology
- Radiopharmacology
Background:
- Prostate-specific membrane antigen (PSMA) radioimmunoscintigraphy offers functional, tissue-specific imaging for prostate cancer.
- This technique complements traditional staging methods in managing prostate cancer.
Purpose of the Study:
- To evaluate the clinical outcomes and utility of PSMA radioimmunoscintigraphy in patients with prostate cancer.
- To assess the role of this imaging modality in staging, detecting recurrence, and guiding treatment decisions.
Main Methods:
- 49 men with prostate cancer underwent prostatic immunoscintigraphy using In-111 CYT 356.
- Sequential 2D and 3D imaging was performed at 10 minutes, 24 hours, and 48 hours post-injection.
Main Results:
- Scans identified lymph node involvement and distant metastases in men with localized disease and recurrence.
- In recurrent disease, scans detected local recurrence, regional, or distant metastases.
- Patients with rising PSA after treatment showed positive scans indicating nodal or distant metastatic disease.
Conclusions:
- Prostatic radio-immunoscintigraphy effectively highlights prostate cancer involvement in the prostate, lymph nodes, soft tissues, and bone.
- The results can inform clinical management, though histological confirmation may be necessary for treatment planning.
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