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Intraovarian stromal artery Doppler indices in predicting ovarian response
Mustafa Altundag1, Rafael Levi, Saban Adakan
1Departments of Obstetrics, Gynecology and Radiology, Ege University Faculty of Medicine, and Family Planning, Infertility Research and Treatment Center, Ege University, Izmir, Turkey.
Objective:
To determine the value of ovarian stromal artery Doppler indices in the prediction of ovarian response in in vitro fertilization-embryo transfer (IVF-ET) cycles.
Study Design:
Forty-five cases were involved in the study. Following controlled ovarian hyperstimulation and detection of at least three follicles > 17 mm in diameter by transvaginal sonography in both ovaries, human chorionic gonadotropin was administered and follicle aspiration performed at the 34th-36th hour. The patients were separated into two groups according to the number of oocytes collected. Group I consisted of 8 (18%) patients who had three or fewer oocytes (low-responder cases); group II consisted of 37 (82%) patients who had 4 or more oocytes (good-response cases).
Results:
A significant negative correlation was found between both the stromal ovarian artery pulsatility index and the number of aspirated follicles (r = -.31, P = .04) and number of oocytes collected (r = -.32, P = .03). Although there was no significant correlation between the resistance index and number of aspirated follicles (r = .24, P = .12), a significant negative correlation was determined between the resistance index and number of oocytes collected (r = -.30, P = .04). Pulsatility and resistance indices were significantly different between the two groups (1.6 +/- 0.5 and 1.2 +/- 0.5, P = .02, versus 0.7 +/- 0.08 and 0.6 +/- 0.08, P = .03, respectively).
Conclusion:
Blood flow in the vessels that supply blood to the follicles in the ovaries in the early follicular phase correlates significantly with ovarian response.