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[Concentrations preventing resistance mutations against fluoroquinolones].
1Laboratoire de Microbiologie, Faculté de pharmacie, 3, rue du Pr Laguesse, BP 83, 59006 Lille. ldubreuil@phare.univ-lille2.fr
Presse Medicale (Paris, France : 1983)
|December 25, 2002
Summary
New fluoroquinolones show broad-spectrum activity but risk resistance. Determining the mutation preventing concentration (MPC) is crucial for preserving antibiotic efficacy against dangerous resistant mutants.
Area of Science:
- Microbiology
- Pharmacology
- Infectious Diseases
Context:
- Fluoroquinolones exhibit broad-spectrum activity against Gram-negative, Gram-positive, intracellular, and anaerobic bacteria.
- Emergence of resistant mutants poses a significant threat to the clinical utility of these agents due to selective pressure.
Purpose:
- To define and establish the mutation preventing concentration (MPC) for various bacterial species.
- To investigate the relationship between MPC and minimum inhibitory concentration (MIC).
Summary:
- The mutation preventing concentration (MPC) is defined as the concentration at which no resistant mutants emerge, even with a high bacterial inoculum.
- MPC values have been determined for Gram-negative bacilli, methicillin-susceptible staphylococci, and pneumococci.
- MPC values are independent of MIC and correlate with the bactericidal potential of fluoroquinolones.
Impact:
- Understanding MPC is vital for developing strategies to prevent the emergence of dangerous, uncharacterized resistant bacterial mutants.
- MPC determination offers a valuable tool for optimizing antibiotic dosing regimens to maintain therapeutic efficacy and combat antimicrobial resistance.