Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Stem cells from cord blood: current status and future potential].

D V Surbek1, W Holzgreve

  • 1Universitäts-Frauenklinik, Basel. surbek@hotmail.com

Therapeutische Umschau. Revue Therapeutique
|December 25, 2002
PubMed
Summary

Umbilical cord blood, rich in hematopoietic stem cells, is a proven source for allogeneic stem cell transplants. While autologous use is currently speculative, future regenerative medicine applications are being explored.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Patient blood management in obstetrics: management of anaemia and haematinic deficiencies in pregnancy and in the post-partum period: NATA consensus statement.

Transfusion medicine (Oxford, England)·2017
Same author

Monitoring and treatment of anti-D in pregnancy.

Vox sanguinis·2010
Same author

Feto-maternal interactions in pregnancies: placental microparticles activate peripheral blood monocytes.

Placenta·2009
Same author

Methylation profiles of 22 candidate genes in breast cancer using high-throughput MALDI-TOF mass array.

Oncogene·2009
Same author

Metastatic involvement of the urinary tract in patients with advanced ovarian carcinoma: lessons from the autopsy for an interdisciplinary treatment approach.

European journal of gynaecological oncology·2009
Same author

Effects of female genital mutilation on birth outcomes in Switzerland.

BJOG : an international journal of obstetrics and gynaecology·2009

Area of Science:

  • Hematology
  • Regenerative Medicine
  • Immunology

Background:

  • Umbilical cord blood (UCB) is a valuable source of hematopoietic stem cells (HSCs).
  • UCB transplantation is an established therapy for various hematologic and genetic disorders.
  • Public and private cord blood banking practices are widespread globally.

Purpose of the Study:

  • To review the current applications of UCB for allogeneic stem cell transplantation.
  • To discuss the scientific and ethical considerations surrounding autologous UCB banking.
  • To explore the potential future applications of UCB in regenerative medicine.

Main Methods:

  • Review of existing literature on UCB collection, HLA-typing, storage, and transplantation.
  • Analysis of current clinical indications for UCB stem cell transplantation.

Related Experiment Videos

  • Discussion of emerging research on stem cell plasticity and regenerative medicine.

    • Main Results:

    • UCB transplantation is a successful alternative to bone marrow and peripheral blood stem cells.
    • Allogeneic UCB transplants are performed using HLA-matched sibling or unrelated donors.
    • Current indications primarily benefit children with leukemia and genetic disorders, with increasing use in adolescents and adults.
    • Autologous UCB banking for future use faces scientific and ethical challenges, with no established indications.
    • The potential for autologous UCB in regenerative medicine remains speculative but promising.

    Conclusions:

    • UCB is a critical resource for allogeneic hematopoietic stem cell transplantation.
    • Autologous UCB transplantation lacks current clinical validation but holds future potential in regenerative medicine.
    • Further research into stem cell differentiation and plasticity is essential to unlock the full therapeutic potential of UCB.