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[Effect of GABA and pyracetam on mitochondrial ADP phosphorylation in experimental hypokinesia]
O P Sotskiĭ1, V P Akopian, L G Zhamgarian
1Department of Pharmacology, Yerevan State Medical University Koryun, st. 2.
Voprosy Meditsinskoi Khimii
|December 25, 2002
Abstract:
Long-term limitation of motor activity of male rats is accompanied by impairments of mitochondrial ADP phosphorylation in liver and heart. The most significant changes were observed after 15 and 45 days of hypokinesia. Administration of GABA and pyracetam to animals subjected to hypokinesia induced a tendency to "normalization" of ADP phosphorilation processes.