Molecular characterization of quinolone-resistant Neisseria gonorrhoeae in Hong Kong
Kai Man Kam1, Shirley Sin Yee Kam, Danny Tze Leung Cheung
1Sexually Transmitted Diseases Laboratory, Public Health Laboratory Centre, Pathology Service, Department of Health, Kowloon, Hong Kong, China. kmkam@dh-gov.hk
Abstract:
In Hong Kong, ParC changes among high-level quinolone-resistant Neisseria gonorrhoeae (QRNG) isolates at Ser-87-->Arg were associated with a higher level of resistance than a Ser-87-->Ile alteration. Two previously undescribed mutations in clinical isolates occurring in gyrA, conferring Ala-92-->Pro and Asp-95-->Tyr changes, were detected. Nine different outer membrane lipoprotein (Lip) repeat classes-11 to 19 repeats-were identified, with repeat lengths of 16 and 17 the most common, indicating considerable strain diversity.
