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Related Experiment Videos

Inflammatory proteins and depression in the elderly.

Henning Tiemeier1, Albert Hofman, H Ruud van Tuijl

  • 1Department of Epidemiology & Biostatistics, Erasmus Medical Centre Rotterdam, the Netherlands.

Epidemiology (Cambridge, Mass.)
|December 25, 2002
PubMed
Summary

Elevated interleukin-6 (IL-6) levels are linked to depressive disorders in older adults, suggesting a potential immunologic factor in depression. Other inflammation markers showed no consistent association.

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Area of Science:

  • Gerontology
  • Psychiatry
  • Immunology

Background:

  • Clinical studies indicate a link between depression and inflammation.
  • This study investigates the relationship between specific inflammatory markers and depression in an elderly population.

Purpose of the Study:

  • To examine the association of interleukin-6 (IL-6), alpha1-antichymotrypsin, and C-reactive protein with depressive symptoms and disorders in older adults.
  • To determine if inflammatory markers are independent predictors of depression in this demographic.

Main Methods:

  • A population-based study screened 3884 adults aged 60+ for depressive symptoms.
  • Psychiatric evaluations and blood draws were conducted.
  • Inflammation marker levels were compared between 263 cases with depressive symptoms and 461 controls, with adjustments for confounders.

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Main Results:

  • Associations between alpha1-antichymotrypsin, C-reactive protein, and depressive disorders were not significant after adjusting for confounding factors.
  • Increased levels of interleukin-6 (IL-6) were significantly associated with depressive disorders (OR=1.47).
  • The IL-6 association appeared to be driven by individuals with high IL-6 concentrations, suggesting a threshold effect.

Conclusions:

  • Elevated interleukin-6 (IL-6) levels may indicate a specific immunologic process in some individuals with depressive disorders.
  • The observed associations of other acute phase proteins with depression were likely due to confounding factors in this population-based study.