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A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
Published on: May 14, 2013
Extracranial internal carotid stenting in Phramongkutklao Hospital
Chumpol Piamsomboon1, Chanwit Rongsrithong, Prasad Laothavorn
1Cardiovascular Division, Phramongkutklao College of Medicine, Bangkok 10400, Thailand.
Insights
Carotid artery stenting is a safe and effective treatment for extracranial stenosis, a common cause of stroke. This procedure significantly reduces stenosis, offering a viable alternative to other interventions.
Area of Science:
- Neurology
- Vascular Surgery
- Interventional Cardiology
Background:
- Carotid artery occlusive disease is a significant cause of stroke, accounting for 20-30% of all cases.
- Extracranial carotid stenosis poses a substantial risk for cerebrovascular events.
Purpose of the Study:
- To evaluate the safety and efficacy of carotid artery stenting for treating extracranial carotid stenosis.
- To assess the outcomes of carotid stenting in patients with significant internal carotid artery stenosis.
Main Methods:
- A cohort of 13 patients with internal carotid stenosis (>= 60%) underwent carotid artery stenting between June 1995 and December 2001.
- Patient eligibility criteria included significant stenosis requiring intervention.
Main Results:
- The mean patient age was 68 years, with 12 males (92%).
- Pre-stenting stenosis averaged 86% +/- 8%, reduced to 18% +/- 15% post-stenting.
- Complications included 2 minor strokes and 1 case of severe bradycardia; one patient died. No new neurological events occurred during follow-up (6-84 months).
Conclusions:
- Carotid stent implantation demonstrates potential as an alternative treatment for extracranial carotid stenosis.
- The procedure achieved significant stenosis reduction with acceptable complication rates in this patient cohort.
Background:
Carotid artery occlusive disease is estimated to be the primary cause in 20-30 per cent of all strokes. This report was to demonstrate the safety and efficacy of the treatment of extracranial stenosis by carotid artery stenting.
Method:
From June 1995 to December 2001, there were 13 patients with internal carotid stenosis > or = 60 per cent who were eligible for carotid stenting.
Results:
Twelve patients were male. The mean age was 68 years old. Fifty-four per cent had neurological symptoms. The percentage of pre stenting stenosis was 86 +/- 8 and the percentage of post stenting stenosis was 18 +/- 15. There were 3 patients who had complications after the procedure (minor stroke = 2, severe bradycardia = 1). One patient died. There were no new or recurrent neurological events during the 6 to 84 month-follow-up.
Conclusions:
Carotid stent implantation may be an alternate treatment for extracranial carotid stenosis.