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Ring and zipper formation is the key to understanding the structural variety in all-beta proteins
Ryotaro Koike1, Kengo Kinoshita, Akinori Kidera
1Department of Chemistry, Graduate School of Science, Kyoto University, Kitashirakawa-Oiwake-cho, Sakyo-ku, Kyoto, 606-8502, Japan. kioke@tsurumi.yokohama-cu.ac.jp
FEBS Letters
|December 31, 2002
Abstract:
A novel structural classification of beta proteins is presented from the viewpoint of the ring-shaped structure and the zipper-like contact pattern, based on the fact that 92% and 60% of beta proteins have the ring topology and the zippered contact pattern, respectively. We discuss the implication of the unexpectedly high preference for the ring and zippered structures in connection with the folding process of beta proteins.