Transporters and xenobiotic disposition
Related Experiment Video
Updated: Jul 28, 2026

Determination of the Transport Rate of Xenobiotics and Nanomaterials Across the Placenta using the ex vivo Human Placental Perfusion Model
Published on: June 18, 2013
1Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University School of Medicine, 572 RRB1, 23rd Avenue at Pierce Avenue, Nashville, TN 37323-6602, USA. richard.kim@mcmail.vanderbilt.edu
Abstract:
Metabolism alone does not adequately account for the observed intersubject variability in drug disposition or response. Carrier-mediated processes, or transporters, are increasingly recognized to be importantly involved in drug absorption, distribution, and excretion. Thus for many drugs, transport and metabolism must be considered together to better predict drug disposition in vivo. Accordingly, this review will outline relevant background information regarding drug transporters and the role of such transporters in the drug disposition process.
Related Concept Videos
Drug Biotransformation: Overview
Carrier-Mediated Transport
Active transport involves two types of membrane-spanning transporters: uptake and efflux. Uptake transporters are expressed in the small...
Hepatic Drug Clearance: Role of Transporters
Physiological Pharmacokinetic Models: Incorporating Hepatic Transporter-Mediated Clearance
A recent model describes pravastatin's hepatobiliary excretion, mediated...
Nonlinear Pharmacokinetics: Role of Transporters
Polymorphisms occurring in drug transporters can alter...
Pharmacogenetics of Drug Transporters: P-Glycoprotein and Solute Carrier Transporters

