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Manganese action in brain function.

Atsushi Takeda1

  • 1Department of Medical Biochemistry, School of Pharmaceutical Sciences, University of Shizuoka, 52-1 Yada, 422-8526, Shizuoka, Japan. takedaa@u-shzuoka-ken.ac.jp

Brain Research. Brain Research Reviews
|December 31, 2002
PubMed
Summary

Manganese is vital for brain function, transported via barriers and influencing neurotransmission. However, abnormal levels can lead to neurological disorders like Parkinson's disease due to its toxic effects.

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Area of Science:

  • Neuroscience
  • Biochemistry
  • Toxicology

Background:

  • Manganese is an essential trace metal crucial for brain function.
  • It crosses the blood-brain and blood-cerebrospinal fluid barriers.
  • Transferrin may play a role in manganese transport into the brain.

Purpose of the Study:

  • To elucidate the mechanisms of manganese transport and its role in the brain.
  • To understand the dual nature of manganese as both essential nutrient and toxicant.
  • To investigate the link between manganese homeostasis and neurological disorders.

Main Methods:

  • Review of existing literature on manganese transport and brain function.
  • Analysis of manganese binding to metalloproteins (e.g., glutamine synthetase).
  • Examination of manganese's dynamic coupling with neuronal electrophysiological activity.

Main Results:

  • Manganese is primarily bound to metalloproteins in astrocytes and stored in synaptic vesicles.
  • Manganese levels are dynamically linked to neuronal activity and can influence synaptic neurotransmission.
  • Dietary manganese deficiency impacts brain manganese homeostasis and neural activity.
  • Excessive manganese exhibits prooxidant activity, contributing to neurotoxicity.

Conclusions:

  • Understanding manganese's synaptic movement and action is key to its function and toxicity.
  • Abnormal brain manganese concentrations are implicated in Parkinson's-like neurological disorders.
  • Further research is needed to clarify manganese's complex role in the central nervous system.

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