Related Experiment Video
Updated: Aug 17, 2026

A Full Skin Defect Model to Evaluate Vascularization of Biomaterials In Vivo
Published on: August 28, 2014
[Repair of skin defect after resection of cutaneous malignant tumor]
Ning Pan1, Jian-ming Liu, Gang Xu
1Department of Plastic Surgery, Sichuan Provincial People's Hospital, Chengdu Sichuan, P. R. China 610072.
Objective:
To investigate the clinical effects of repairing skin defect after resection of cutaneous malignant tumors.
Methods:
From 1984 to 2001, cutaneous malignant tumors of 38 patients were resected and diagnosed pathologically. There were 12 cutaneous squamous cancer, 14 carinal cutaneous fibrosarcomas, 2 in situ cancers, 1 wart like cancer, 4 eczematoid cancers, and 5 deteriorative chronic ulcers. The biggest skin defect was 14 cm x 20 cm in size. Skin defects were repaired with flaps, myocutaneous flaps, free skin grafts and suturations. There were 4 gastronomies flaps, 6 latissimus flaps, 2 tensor fascia lata myocutaneous flaps, 1 transverse recuts abdominis myocutaneous flap, 5 plantaris medialis flaps, 3 random flaps, 12 free skin grafts and 5 suturings.
Results:
All the operations succeed. Among 21 cases followed up for 3 to 12 years, 19 healed and 2 relapsed, but the 2 patients healed after second operation.
Conclusion:
Thorough resection of tumor is the key to eradicate malignant tumor. The method to repair skin defect after resection should be chosen according to the patients individually.
Related Concept Videos
Clinical Applications of Epidermal Stem Cells
Overview of Regeneration and Repair
Regeneration
All animals have varying degrees of...
Phases of Wound Repair
Formation of Blood Clot
In case of deep injuries, trauma to blood vessels results in blood loss. In the meantime, phospholipids released from the ruptured endothelial cellular membrane are converted into arachidonic...
Skin Cancer
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Burn Injuries
The damage results in the death of skin cells, which can lead to a massive loss of fluid. Dehydration, electrolyte imbalance, and renal and circulatory failure follow, which can be fatal. Burn patients are treated with intravenous fluids to offset...
Healing II: Complications

