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A guide to drug discovery: Target selection in drug discovery
Jonathan Knowles1, Gianni Gromo
1F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070, Basel, Switzerland. jonathan.knowles@roches.com
Nature Reviews. Drug Discovery
|January 2, 2003
Abstract:
Target selection in drug discovery--defined here as the decision to focus on finding an agent with a particular biological action that is anticipated to have therapeutic utility--is influenced by a complex balance of scientific, medical and strategic considerations. In this article, we provide an introduction to the key issues in target selection and discuss the rationale for decision making.