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Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Combination Therapies and Personalized Medicine02:50

Combination Therapies and Personalized Medicine

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Tumor Immunotherapy01:27

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

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Updated: Jun 18, 2026

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care
12:55

Generation of CAR T Cells for Adoptive Therapy in the Context of Glioblastoma Standard of Care

Published on: February 16, 2015

Targeting tumours with genetically enhanced T lymphocytes.

Michel Sadelain1, Isabelle Rivière, Renier Brentjens

  • 1Department of Medicine and Immunology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. m-sadelain@ski.mskcc.org

Nature Reviews. Cancer
|January 2, 2003
PubMed
Summary

Genetic modification of T lymphocytes is key for understanding T-cell biology and boosting anti-tumor immunity. Engineered T cells offer improved safety and tracking for immunotherapy research.

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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
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Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates
06:10

Non-Viral Engineering of Primary Human T Cells via Homology-Mediated End-Joining Targeted Integration of Large DNA Templates

Published on: May 9, 2025

Area of Science:

  • Immunology
  • Cell Biology
  • Genetic Engineering

Background:

  • T lymphocytes are crucial for immune responses, including anti-tumor immunity.
  • Understanding T-cell biology is essential for developing new therapies.
  • Genetic modification offers powerful tools to study and enhance T-cell functions.

Purpose of the Study:

  • To explore the applications of genetically modified T lymphocytes in basic immunology.
  • To investigate strategies for enhancing anti-tumor immunity through T-cell engineering.
  • To highlight the potential of engineered T cells in experimental immunotherapy.

Main Methods:

  • Genetic strategies to enhance tumor antigen recognition.
  • Engineering T cells for improved anti-tumor activity.
  • Methods to prevent T-cell malfunction and increase safety.
  • Incorporation of markers for non-invasive imaging.

Main Results:

  • Genetically modified T cells show promise in basic immunology research.
  • Engineered T cells can be designed to target tumor antigens more effectively.
  • Strategies exist to improve T-cell safety and functionality.
  • Tracking capabilities can be integrated into engineered T cells.

Conclusions:

  • Genetically modified T lymphocytes are valuable tools for immunological research.
  • T-cell engineering holds significant potential for advancing experimental immunotherapy.
  • Further development of these strategies can lead to improved cancer treatments.