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Meningioma presenting with Cushing's syndrome: an unusual clinical presentation
Francesca Pecori Giraldi1, Maria Rosa Terreni, Claudia Andreotti
1Istituto Scientifico Ospedale San Luca Istituto Auxologico Italiano IRCCS, University of Milan, Italy. fpg@auxologico.it
Annals of Neurology
|January 2, 2003
Abstract:
We report a patient with a meningioma presenting with Cushing's syndrome, an unprecedented paraneoplastic presentation. Molecular studies, bioassay, and high-performance liquid chromatography of tumor specimens demonstrated the synthesis and secretion of bioactive corticotropin-releasing hormone. To our knowledge, this appears to be the first report of a hormone-secreting meningioma and, further, the first clearly proven case of Cushing's syndrome due to ectopic corticotropin-releasing hormone secretion without concomitant corticotropin production.