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Accelerating water exchange for GdIII chelates by steric compression around the water binding site
Robert Ruloff1, Eva Tóth, Rosario Scopelliti
1Ecole Polytechnique Fédérale de Lausanne, ICMB, BCH, Lausanne, Switzerland.
Chemical Communications (Cambridge, England)
|January 4, 2003
Abstract:
The water exchange process was accelerated for nine-coordinate, monohydrated macrocyclic GdIII complexes by inducing steric compression around the water binding site; the increased steric crowding was achieved by replacing an ethylene bridge of DOTA4- by a propylene bridge; in addition to the optimal water exchange rate, the stability of [Gd(TRITA)(H2O)]- is sufficiently high to ensure safe medical use which makes it a potential synthon for the development of high relaxivity, macromolecular MRI contrast agents.