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Motexafin gadolinium reacts with ascorbate to produce reactive oxygen species
Darren Magda1, Nikolay Gerasimchuk, Philip Lecane
1Pharmacyclics, Inc., 995 E. Arques Avenue, Sunnyvale, CA 94085, USA. dmagda@pcyc.com
Chemical Communications (Cambridge, England)
|January 4, 2003
Abstract:
Motexafin gadolinium (MGd) oxidizes ascorbate, in neutral buffer and in cell culture, forming reactive oxygen species and a coordination polymer with oxalate.
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