Related Experiment Video
Updated: Sep 20, 2026

Differentiating Functional Roles of Gene Expression from Immune and Non-immune Cells in Mouse Colitis by Bone Marrow Transplantation
Published on: October 1, 2012
[Cross-talk between immune and skeletal systems]
1Department of Immunology, Faculty of Medicine and Graduate School of Medicine, University of Tokyo.
Abstract:
Bone destruction in rheumatoid arthritis is characterized as 'the defective control of bone metabolism by the immune system'. During the course of our study to investigate the mechanism of arthritic bone destruction, we have explored a new field called' osteo-immunology'. Here we summarize the regulation of the bone metabolism by signalling cross-talk between RANKL and IFNs, focusing on the T cell-mediated regulation of osteoclastogenesis by IFN-gamma. The better understanding of the interactions between bone and immune cells will provide further insights into the both fields.
Related Concept Videos
What is the Immune System?
Cell-mediated Immune Responses
Humoral Immune Responses
Functions of the Lymphatic and Immune System
The primary lymphoid organs, including the bone marrow and the thymus, serve as the maturation sites for lymphocytes. Secondary lymphoid organs, like the mucosa-associated lymphoid tissue, activate these lymphocytes and serve as...
Special Features of Adaptive Immunity
The primary cell types involved in adaptive immunity are T cells and B cells. Each type has a unique role in defending the body against pathogens. T cells are responsible for cell-mediated immunity. They identify and eliminate infected cells directly,...
T Cell Types and Functions
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...

