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[Infliximab in the treatment of rheumatoid arthritis]

Tohru Akahoshi1, Hiroyuki Watabe

  • 1Department of Laboratory Medicine, Kitasato University School of Medicine.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 4, 2003
PubMed

Infliximab is a chimeric monoclonal antibody capable of neutralizing human TNF alpha. A number of clinical trials for the treatment of rheumatoid arthritis(RA) with infliximab indicated that TNF alpha blockade was effective and well tolerated with the excellent results occurring at 3 and 10 mg/kg in combination with methotrexate. Treatment of RA patients with the combination of infliximab and methotrexate also prevented radiographic evidence of progression of joint damage. If the clinical efficacy is sustained and the safety is confirmed over the long term, infliximab may become an essential agent of choice for the treatment of RA.

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