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Total synthesis of a norneolignan from Ratanhia radix
Hong-Dae Choi1, Pil-Ja Seo, Byeng-Wha Son
1Department of Chemistry, Dongeui University, Busan 614-714, Korea. hdchoi@dongeui.ac.kr
Archives of Pharmacal Research
|January 4, 2003
Abstract:
The total synthesis of a norneolignan isolated from Ratanhia, 5-(3-hydroxypropyl)-2-(2-methoxy-4'-hydroxyphenyl)benzofuran (8), is described. The key steps contain the one-pot reaction for a 2-arylbenzofuran 6 from methyl 3-(4-hydroxyphenyl)propionate with 2-chloro-2-methylthio-(2'-methoxy-4'-acetoxy)acetophenone (5) in the presence of ZnCl2, and reductive desulfurization of the resulting product 6.