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Hypoglycemic activity of ginseng glycopeptide
Ben-Xiang Wang1, Qiu-Li Zhou, Ming Yang
1Jilin Institute of Natural Medicine, Jilin University, Changchun 130021, China. cctcmwbx@public.cc.jl.cn
Aim:
To study the hypoglycemic activity of ginseng glycopeptide (GGP).
Methods:
Normal mice or rabbits and alloxan or streptozotocin-induced hyperglycemic rats or mice were used in the study. Blood glucose and liver glycogen levels of the experimental animals during the trial period were analyzed by spectrophotometry with O-toluidine and iodine reagents, respectively.
Results:
Significant decreases in blood glucose and liver glycogen levels were induced in a dose-dependent manner after administration of GGP 50, 100, or 200 mg/kg injected ip or sc to normal mice and injected im 30 or 60 mg/kg to normal rabbits. The hypoglycemic activity of GGP lasted for about 16 h, and were examined in both normal animals and hyperglycemic animals.
Conclusion:
GGP injection induced the pronounced decreases in blood glucose and liver glycogen levels in both normal and hyperglycemic animals.