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Related Concept Videos

Binary Fission01:20

Binary Fission

Fission is the division of a single entity into two or more parts, which regenerate into separate entities that resemble the original. Organisms in the Archaea and Bacteria domains reproduce using binary fission, in which a parent cell splits into two parts that can each grow to the size of the original parent cell. This asexual method of reproduction produces cells that are all genetically identical.
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DNA replication is carried out by a large complex of proteins that act in a coordinated matter to achieve high-fidelity DNA replication. Together this complex is known as the DNA replication machinery or the replisome.
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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent years,...
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Binary fission is the primary mode of asexual reproduction in prokaryotes, such as bacteria. It results in the production of two genetically identical daughter cells. This highly efficient process ensures the rapid propagation of bacterial populations under favorable conditions and involves coordinated cellular and molecular events.DNA Replication and SeparationThe process begins with the replication of the bacterial chromosome. The circular DNA molecule unwinds at a specific origin of...

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Related Experiment Video

Updated: May 7, 2026

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization
17:14

Chromosome Replicating Timing Combined with Fluorescent In situ Hybridization

Published on: December 10, 2012

Replicating by the clock.

Alon Goren1, Howard Cedar

  • 1Department of Cellular Biochemistry and Human Genetics, Hebrew University, Ein Kerem, Jerusalem 91120, Israel.

Nature Reviews. Molecular Cell Biology
|January 4, 2003
PubMed
Summary
This summary is machine-generated.

Active genes replicate early in the eukaryotic cell cycle, while inactive genes replicate late. This differential DNA replication timing may be linked to changes in chromatin structure during S phase.

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Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons
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Alignment of Synchronized Time-Series Data Using the Characterizing Loss of Cell Cycle Synchrony Model for Cross-Experiment Comparisons

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Area of Science:

  • Genomics
  • Molecular Biology
  • Cell Biology

Background:

  • The eukaryotic genome is organized into distinct DNA regions.
  • DNA replication occurs at specific times during the S phase of the cell cycle.
  • Gene activity correlates with replication timing: active genes replicate early, inactive genes replicate late.

Purpose of the Study:

  • To explore the relationship between DNA replication timing and gene expression.
  • To investigate the potential role of chromatin restructuring in regulating replication timing and gene expression patterns.

Main Methods:

  • Analysis of DNA replication timing across different genomic regions.
  • Correlation of replication timing with gene activity status (active vs. inactive genes).
  • Examination of chromatin structure modifications in relation to replication timing.

Main Results:

  • Confirmation that active genes are predominantly replicated during early S phase.
  • Observation that inactive genes are typically replicated during late S phase.
  • Evidence suggesting that differential chromatin restructuring at the time of replication may underlie this temporal separation.

Conclusions:

  • Replication timing is a programmed process in eukaryotic genomes.
  • Chromatin structure plays a crucial role in mediating the differential replication timing of active and inactive genes.
  • This mechanism likely contributes to the establishment and maintenance of gene expression patterns.