Adsorption of a random copolymer at a lipid bilayer membrane

Aleksander V Ermoshkin¹, Jeff Z Y Chen, Pik-Yin Lai

¹Department of Physics, University of Waterloo, Ontario, Canada N2L 3G1.

Physical Review. E, Statistical, Nonlinear, and Soft Matter Physics

|January 7, 2003

Abstract:

We examine the conformational properties of a random copolymer, containing a disordered hydrophobic/hydrophilic sequence of monomers, in the presence of a hydrophobic potential well. The model can be used to understand the structural properties of the adsorption of a protein molecule at a lipid-bilayer membrane, and the properties of a random copolymer at the surfaces of a microphase-separated layered polymer structure. Using a trial-potential treatment we demonstrate that a mainly hydrophilic chain may localize on the surface of the bilayer and that a mainly hydrophobic chain may have two typical conformations: localization on the surface or complete adsorption inside the two surfaces.

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Adsorption of a random copolymer at a lipid bilayer membrane

Abstract:

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