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Comparison and validation of novel pyrogen tests based on the human fever reaction
1University of Konstanz, Steinbeis-Technology Transfer Center for In Vitro Pharmacology and Toxicology (STZ InPuT), 78457 Konstanz, Germany.
Abstract:
The Limulus amoebocyte lysate (LAL) test has replaced about 80% of the use of the rabbit pyrogen test. Ideally, human-based in vitro tests are needed, to replace the remaining use of the rabbit test and the use of the LAL test. The progress of an EU-funded project is described, in which a number of in vitro tests, based on the human fever reaction are passing through a prevalidation study on the way to evaluation in a formal validation study.
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