[Changes in the cytological analysis of nasal secretions during a nasal secretion]

Changes of cytological parameters in the course of the nasal provocative test (NPT) we studied in 30 patients aged 14-43 years with chronic rhinitis of unknown etiology. Solutions of allergens in various concentrations were used for NPT and skin testing. NPT results were estimated clinically according to four-point scale and rhinocytogram 20 minutes after injection of different concentrations of allergens to nasal cavity. The results of the provocative tests coincide with case history data more frequently than skin test results. The discrepancy between anamnesis and results of skin tests in the group of patients reached 30.7%. A mean 8-fold increase in eosinophil count in nasal secretion was observed in patients with clinically confirmed NPT (76% cases) 20 minutes after injection of a minimal concentration of allergen extract to the nasal cavity. This eosinophil infiltration of nasal secretion preceded the occurrence of clinical symptoms. An unusual cytological picture of nasal secretion was observed in three patients with positive anamnestic data, results of skin testing and NPT. Eosinophil infiltration of nasal recreation was absent but neutrophil number increased. Increased eosinophil count on rhinocytogram after injection of allergen extract to nasal cavity can serve as an objective criterion of NPT. The described cases of neutrophil infiltration of nasal secretion testify to possible participation of these cells in acute allergic inflammation in patients with clinically positive NPT.