[Clinical manifestations of neuroendocrine tumors]

A complex clinico-functional morphologic examination was carried out on 125 patients with neuroendocrine tumors (NET): carcinoids, pheochromocytoma and multiple endocrine adenomatosis (an integral part of which is pheochromocytoma, gastrinoma and medullar C-cell carcinoma of thyroid gland). There was a clinical examination using laboratory and instrumental methods in pre- and postoperative periods, morphological research of removed tumors. According to the obtained indications, selective angiography and static scintigraphy with 111Tc was carried out. Isotopes 111-In were used in 3 patients for scintigraphic research of somatostatinpositive NET. The following versions were selected: serotonin and sympathoadrenal clinical variants of monoaminoforming NET, clinical versions of multiple endocrine neoplasias, a clinical version of adenocarcinomas having in their composition cells with neuroendocrine differentiation accompanied by neuroendocrine paraneoplastic syndrome. There were offered a term and definitions of hyperproduction syndrome of regulatory peptides in case of NET.