Search research articles

Search research articles

Related Experiment Videos

Dip-pen nanolithography in tapping mode.

Gunjan Agarwal¹, Laura A Sowards, Rajesh R Naik

¹Materials and Manufacturing Directorate, Air Force Research Laboratory, Wright-Patterson Air Force Base, Ohio 45433, USA.

Journal of the American Chemical Society

|January 9, 2003

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Effect of ionic strength on the flexibility of Col IV molecules.

Journal of the mechanical behavior of biomedical materials·2026

Same author

How do you measure a threat in the air? Testing the universal, dynamic, and multifaceted nature of social identity threat.

Science advances·2026

Same author

Ultrastructural Analysis of In Vitro Glycated Engineered Skin.

Journal of cosmetic dermatology·2026

Same author

Nano-mechanical mapping of human and porcine abdominal aortic aneurysm.

Journal of the mechanical behavior of biomedical materials·2025

Same author

33 Unresolved Questions in Nanoscience and Nanotechnology.

ACS nano·2025

Same author

Understanding the role of toggle genes in chronic lymphocytic leukemia proliferation.

NPJ systems biology and applications·2025

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Dip-pen nanolithography (DPN) using atomic force microscopy (AFM) Tapping Mode enables gentle peptide deposition on soft surfaces. This novel approach modifies DPN for improved material imaging and broader substrate compatibility.

Area of Science:

Nanoscience and Nanotechnology
Surface Science
Biomaterials Engineering

Background:

Dip-pen nanolithography (DPN) is a versatile nano-patterning technique.
DPN commonly utilizes the contact mode of atomic force microscopy (AFM).
Limitations exist in contact mode DPN for soft materials and gentle imaging.

Purpose of the Study:

To demonstrate peptide deposition using DPN in AFM Tapping Mode.
To explore the advantages of Tapping Mode over Contact Mode for DPN.
To enable nano-patterning on soft and delicate surfaces.

Main Methods:

Utilized atomic force microscopy (AFM) in Tapping Mode for dip-pen nanolithography (DPN).
Optimized DPN parameters, specifically drive amplitude modifications, for peptide deposition.

Related Experiment Videos

Characterized the deposited synthetic peptide patterns on the substrate.

Main Results:

Successfully deposited a short synthetic peptide using DPN in Tapping Mode.
Tapping Mode DPN allowed for gentle imaging of the deposited peptide.
Demonstrated the feasibility of DPN on soft surfaces, which is challenging with contact mode.

Conclusions:

DPN in AFM Tapping Mode offers a viable alternative to contact mode for specific applications.
This method enhances the capability of DPN for patterning delicate materials and soft substrates.
The technique provides improved control and imaging during nano-deposition processes.