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Recent developments in antiangiogenic therapy

Keith Dredge1, Angus G Dalgleish, J Blake Marriott

  • 1Division of Oncology, St. George's Hospital Medical School, Jenner Wing, Cranmer Terrace, Tooting SW17 0RE, London, UK. k.dredge@sghms.ac.uk

Expert Opinion on Biological Therapy
|January 9, 2003
PubMed

Insights

Antiangiogenic therapy, targeting new blood vessel formation, shows promise for diseases like cancer and psoriasis. Further research is needed to overcome limitations and optimize treatment strategies for better patient outcomes.

Area of Science:

  • Oncology
  • Vascular Biology
  • Dermatology

Background:

  • Angiogenesis, the formation of new blood vessels, is crucial for tumor growth and progression.
  • Antiangiogenic therapy emerged as a potential treatment for various diseases, including cancer and psoriasis.
  • Initial clinical trials for antiangiogenic therapy in cancer yielded disappointing results, necessitating reassessment.

Purpose of the Study:

  • To review the role of angiogenesis in diverse pathological conditions.
  • To discuss emerging antiangiogenic agents in preclinical and clinical development.
  • To explore strategies for enhancing the efficacy of antiangiogenic therapy.

Main Methods:

  • Literature review of preclinical and clinical studies on antiangiogenic agents.
  • Analysis of the angiogenic process, its inducers, and mediators.
  • Discussion of therapeutic strategies, including drug scheduling and combination therapies.

Main Results:

  • Angiogenesis is implicated in difficult-to-treat conditions like arteriosclerosis, arthritis, psoriasis, and diabetic retinopathy.
  • New strategies are being developed to improve the efficacy of antiangiogenic therapy in cancer.
  • Emerging antiangiogenic agents are under investigation in preclinical and clinical studies.

Conclusions:

  • A deeper understanding of angiogenesis can lead to novel treatment regimens for various diseases.
  • While antiangiogenic therapy holds profound potential benefits, its limitations necessitate cautious clinical application.
  • Optimizing drug schedules and combining antiangiogenic agents with other modalities may improve treatment outcomes.

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