Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Interventions for treating tuberculous pericarditis.

B M Mayosi1, M Ntsekhe, J A Volmink

  • 1The Cardiac Clinic, E25 Groote Schuur Hospital, Observatory 7925, Cape Town, South Africa. bmayosi@uctgsh1.uct.ac.za

The Cochrane Database of Systematic Reviews
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The clinical utility of tissue polymerase chain reaction, tissue culture and tissue histology in blood culture-negative infective endocarditis in South Africa - insights from the Groote Schuur Hospital Infective Endocarditis Registry.

South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde·2025
Same author

Inter-organ communication: pathways and targets to cardioprotection and neuro-protection. A report from the 12th Hatter Cardiovascular Institute workshop.

Basic research in cardiology·2024
Same author

Clinical and cardiovascular magnetic resonance profile of cardiomyopathy patients from South Africa: Pilot of the IMHOTEP study.

International journal of cardiology·2024
Same author

From the Editor's Desk.

Cardiovascular journal of Africa·2023
Same author

From the Editor's Desk.

Cardiovascular journal of Africa·2023
Same author

From the Editor's Desk.

Cardiovascular journal of Africa·2023

Tuberculous pericarditis treatments like steroids show potential benefits but require larger trials for definitive proof. Surgical drainage can relieve cardiac tamponade, but further evaluation of other procedures is needed.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Clinical Trials

Background:

  • Tuberculous pericarditis, an infection of the heart's outer membrane, is increasing.
  • It can lead to fatal fluid accumulation or scarring of the pericardium.

Purpose of the Study:

  • To evaluate treatments for tuberculous pericarditis, including drug regimens, corticosteroids, pericardial drainage, and pericardiectomy.
  • Assess effects on mortality, critical conditions, and long-term disability.

Main Methods:

  • Systematic review of randomized and quasi-randomized controlled trials.
  • Searched multiple databases (Cochrane, MEDLINE, EMBASE) and contacted experts.
  • Meta-analysis used fixed-effects models to calculate relative risks.

Related Experiment Videos

Main Results:

  • Four trials with 469 participants evaluated adjuvant steroids and surgical drainage.
  • Steroids showed a trend towards reduced mortality in pre-HIV era (RR 0.65) and HIV-positive participants (RR 0.50), though not statistically significant.
  • Surgical drainage effectively relieved cardiac tamponade.

Conclusions:

  • Steroids may offer clinical benefits, but current trials are too small to confirm.
  • Larger placebo-controlled trials are necessary to establish efficacy.
  • Further research is needed on therapeutic pericardiocentesis and pericardiectomy.