Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Recombinant DNA

Recombinant DNA

No description available

Recombinant DNA

Recombinant DNA

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

Genetic Material

Genetic Material

Within the human body, a complex and detailed system of trillions of cells works in unison to sustain life. Each cell houses a nucleus, which contains 46 chromosomes divided into 23 pairs. Chromosomes are highly coiled structures made of the genetic material DNA. These chromosomes are essential carriers of genetic information, with half inherited from the mother through her egg and the other half from the father's sperm, combining to create the unique genetic makeup of an individual.

Genome Annotation and Assembly

Genome Annotation and Assembly

The genome refers to all of the genetic material in an organism. It can range from a few million base pairs in microbial cells to several billion base pairs in many eukaryotic organisms. Genome assembly refers to the process of taking the DNA sequencing data and putting it all back together in a correct order to create a close representation of the original genome. This is followed by the identification of functional elements on the newly assembled genome, a process called genome annotation.

Genomics

Genomics

Genomics is the science of genomes: it is the study of all the genetic material of an organism. In humans, the genome consists of information carried in 23 pairs of chromosomes in the nucleus, as well as mitochondrial DNA. In genomics, both coding and non-coding DNA is sequenced and analyzed. Genomics allows a better understanding of all living things, their evolution, and their diversity. It has a myriad of uses: for example, to build phylogenetic trees, to improve productivity and...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Genomic epidemiology of <i>Salmonella</i> and <i>Campylobacter</i> in poultry production: Quantifying the contribution of primary breeders.

Proceedings of the National Academy of Sciences of the United States of America·2026

Same author

Beyond Euglycemia: Case Studies Using Continuous Glucose Monitoring in Elite Athletes Without Diabetes During Record Athletic Events.

Sensors (Basel, Switzerland)·2026

Same author

Continuous Glucose Monitoring-Derived Glucose Metrics Over Time in Physically Active Adults Without Diabetes Using a Commercial Continuous Glucose Monitoring Application.

Journal of diabetes science and technology·2026

Same author

Artificial Intelligence-Based Tools for Automated Genus-Level Identification of Plant-Parasitic Nematodes.

Phytopathology·2026

Same author

Continuous Glucose Monitoring Profiles in Elite-Level Professional European Football Players.

Journal of diabetes science and technology·2025

Same author

Minimum Overnight Interstitial Glucose Concentration in Professional Cyclists During Two Consecutive Annual Training Camps: The Limited Impact of Daily Exercise Energy Expenditure.

International journal of sport nutrition and exercise metabolism·2024

Same journal

Correction to 'New origin firing is inhibited by APC/CCdh1 activation in S-phase after severe replication stress'.

Nucleic acids research·2026

Same journal

VeloRM: disentangling pre- and post-splicing RNA modification dynamics at single-cell resolution.

Nucleic acids research·2026

Same journal

Accessibility of telomeric overhangs to stabilizing small-molecule ligands.

Nucleic acids research·2026

Same journal

Multivalent interactions mediate SNAIL transcription factor stimulation of the nucleosome deacetylase activity of the CoREST complex.

Nucleic acids research·2026

Same journal

Genome-wide mapping of DNA G-quadruplexes in Trypanosoma brucei chromatin reveals enrichment in coding regions and transcription start sites.

Nucleic acids research·2026

Same journal

Correction to 'The Gene Ontology knowledgebase in 2026'.

Nucleic acids research·2026

See all related articles

Search research articles

Related Experiment Video

Updated: Mar 23, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

GenBank.

Dennis A Benson¹, Ilene Karsch-Mizrachi, David J Lipman

¹National Center for Biotechnology Information, National Library of Medicine, National Institutes of Health, Building 38A, 8600 Rockville Pike, Bethesda, MD 20894, USA.

Nucleic Acids Research

|January 10, 2003

Summary

This summary is machine-generated.

GenBank is a vital public DNA sequence database covering over 119,000 organisms. It facilitates global research through daily updates and integration with other biological databases and literature via Entrez.

More Related Videos

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Published on: March 28, 2018

Related Experiment Videos

Last Updated: Mar 23, 2026

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Biobank for Translational Medicine: Standard Operating Procedures for Optimal Sample Management

Published on: November 30, 2022

Creation and Maintenance of a Living Biobank - How We Do It

Creation and Maintenance of a Living Biobank - How We Do It

Published on: April 10, 2021

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Generating Transgenic Plants with Single-copy Insertions Using BIBAC-GW Binary Vector

Published on: March 28, 2018

Area of Science:

Bioinformatics
Genomics
Molecular Biology

Background:

GenBank is a major public repository for DNA sequences.
It aggregates data from individual labs and large-scale sequencing initiatives.
Global data sharing is maintained through daily exchange with EMBL and DDBJ.

Purpose of the Study:

To describe the GenBank database and its functionalities.
To highlight its role in the scientific community.
To provide access information for researchers.

Main Methods:

Data submission via BankIt and Sequin.
Automated accession number assignment.
Daily data synchronization with international partners (EMBL, DDBJ).

Main Results:

GenBank houses sequences from over 119,000 organisms.
Integrated access through NCBI's Entrez system.
Sequence similarity searches enabled by BLAST.

Conclusions:

GenBank is an essential, comprehensive resource for biological sequence data.
Its integration with Entrez and PubMed enhances data retrieval and analysis.
Regular updates and FTP access ensure broad availability for scientific research.