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Related Experiment Videos

PlasmoDB: the Plasmodium genome resource. A database integrating experimental and computational data.

Amit Bahl1, Brian Brunk, Jonathan Crabtree

  • 1Department of Biology, University of Pennsylvania, Philadelphia, PA 19104, USA.

Nucleic Acids Research
|January 10, 2003
PubMed
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PlasmoDB is a comprehensive database for Plasmodium falciparum and related species, integrating genomic and expression data. It offers tools for comparative genomics and data access, aiding malaria research globally.

Area of Science:

  • Parasitology
  • Bioinformatics
  • Genomics

Background:

  • PlasmoDB is the official genome database for Plasmodium falciparum.
  • It integrates genomic data from multiple Plasmodium species and related research projects.
  • The database supports intra- and inter-species comparisons.

Purpose of the Study:

  • To provide a centralized resource for Plasmodium genomic and expression data.
  • To facilitate the utilization of large-scale genomic data by the malaria research community.
  • To offer tools for complex data querying and analysis.

Main Methods:

  • Incorporation of completed P. falciparum genome sequence and annotation.
  • Integration of draft sequences and annotations from other Plasmodium projects.

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  • Utilizing the Genomics Unified Schema (GUS) relational database model.
  • Inclusion of gene expression data (EST, SAGE, microarray) and proteomics studies.

    • Main Results:

    • PlasmoDB houses information from five parasite species.
    • Tools are available for comparative genomic analyses.
    • Genomic data is integrated with functional genomics data.
    • A stand-alone version (P. falciparum GenePlot) is available on CD-ROM.

    Conclusions:

    • PlasmoDB serves as a vital resource for malaria researchers.
    • The database facilitates access to and analysis of extensive genomic data.
    • The underlying software supports the development of other parasite databases, such as ToxoDB.