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KDBI: Kinetic Data of Bio-molecular Interactions database
1Department of Computational Science, National University of Singapore, Blk SOC 1, Level 7, 3 Science Drive 2, 117543 Singapore.
Nucleic Acids Research
|January 10, 2003
Summary
A new database, Kinetic Data of Bio-molecular Interactions (KDBI), provides crucial kinetic data for biomolecular interactions. This resource aids in understanding cellular processes by compiling experimentally determined binding and reaction rates from scientific literature.
Area of Science:
- Biochemistry
- Molecular Biology
- Bioinformatics
Background:
- Cellular processes rely on molecular interactions, networks, and pathways.
- Existing databases lack essential kinetic data for mechanistic studies and simulations.
- Kinetic data is vital for quantitative analysis of cellular events.
Purpose of the Study:
- To introduce the Kinetic Data of Bio-molecular Interactions (KDBI) database.
- To provide experimentally determined kinetic data for biomolecular interactions.
- To facilitate research on cellular processes through accessible kinetic information.
Main Methods:
- Compiled experimentally determined kinetic data from scientific literature.
- Included data on protein-protein, protein-nucleic acid, and protein-ligand interactions.
- Structured data with details on participating molecules, reaction equations, and kinetic parameters.
Main Results:
- The KDBI database contains 8273 entries of biomolecular binding or reaction events.
- It involves 1380 proteins, 143 nucleic acids, and 1395 small molecules.
- Entries are searchable by molecule name, identifiers, and full-text search.
Conclusions:
- KDBI addresses the gap in readily available kinetic data for biomolecular interactions.
- The database supports mechanistic investigations and quantitative studies of cellular events.
- Provides hyperlinks to Medline references and 3D structure databases (PDB, NDB).