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The Homeodomain Resource: 2003 update.

Sharmila Banerjee-Basu1, Travis Moreland, Benjamin J Hsu

  • 1Genome Technology Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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The Homeodomain Resource is a comprehensive database for homeodomain proteins, offering curated data on sequences, structures, and interactions. This updated version includes new protein-protein interaction data, enhancing its utility for researchers.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Homeodomain proteins are crucial transcription factors involved in development and disease.
  • A centralized, curated resource is needed to consolidate information on this protein family.

Purpose of the Study:

  • To present an updated version of the Homeodomain Resource, a comprehensive database for homeodomain proteins.
  • To enhance the resource with new data types and improved accessibility.

Main Methods:

  • Curated data collection from various sources.
  • Database organization with user-friendly query interfaces.
  • Integration of new experimental data, including protein-protein interactions.

Main Results:

Related Experiment Videos

  • The resource now contains 1056 full-length homeodomain sequences, 37 structures, 81 interactions, 84 DNA-binding sites, and 114 proteins linked to human genetic disorders.
  • Version 5.0 includes experimentally-derived protein-protein interaction data.
  • All entries are cross-linked for easy retrieval from source databases.

Conclusions:

  • The Homeodomain Resource provides a valuable, integrated platform for studying homeodomain proteins.
  • The inclusion of new data types and cross-linking facilitates research in developmental biology, genetics, and disease.
  • The resource is freely accessible online, promoting wider scientific use.