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Related Experiment Videos

NRMD: Nuclear Receptor Mutation Database.

Joost J J Van Durme1, Emmanuel Bettler, Simon Folkertsma

  • 1CMBI, University of Nijmegen, Nijmegen, The Netherlands.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
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The Nuclear Receptor Mutation Database (NRMD) centralizes nuclear receptor mutation data from multiple sources, including automated literature extraction and manual curation. This comprehensive resource aids diverse research studies on nuclear receptors.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Nuclear receptors play crucial roles in cellular processes and disease.
  • Accurate and comprehensive mutation data is essential for understanding nuclear receptor function and dysfunction.
  • Existing data resources were fragmented and lacked a unified approach.

Purpose of the Study:

  • To develop and present the Nuclear Receptor Mutation Database (NRMD).
  • To consolidate nuclear receptor mutation information from diverse sources into a single, accessible platform.
  • To facilitate research by providing a standardized data format and a common numbering scheme.

Main Methods:

  • Integrated data from SWISS-PROT/TrEMBL and other web resources.
  • Employed automated text mining for literature data extraction.

Related Experiment Videos

  • Incorporated manual curation for data completeness, adding 100 mutations.
  • Developed a common numbering scheme for all nuclear receptors.

    • Main Results:

    • The NRMD currently contains information on 893 mutations across 54 nuclear receptors.
    • Data is sourced from SWISS-PROT/TrEMBL, web resources, and literature.
    • A standardized numbering system simplifies comparative analysis.
    • The database is freely available for academic and industrial use.

    Conclusions:

    • The NRMD provides a valuable, centralized resource for nuclear receptor mutation data.
    • Its comprehensive nature and standardized format support various research applications.
    • The database enhances the study of nuclear receptor-related diseases and functions.