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Related Experiment Videos

IRESdb: the Internal Ribosome Entry Site database.

Sophie Bonnal1, Christel Boutonnet, Leonel Prado-Lourenço

  • 1INSERM U397, Institut Louis Bugnard, CHU Rangueil, 31043 Toulouse, France.

Nucleic Acids Research
|January 10, 2003
PubMed
Summary
This summary is machine-generated.

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Internal Ribosome Entry Sites (IRES) are RNA sequences that help start protein production. A new database catalogs these diverse IRES sequences, aiding research into gene expression.

Area of Science:

  • Molecular Biology
  • Genetics
  • Bioinformatics

Background:

  • Internal Ribosome Entry Sites (IRES) are cis-acting RNA elements facilitating cap-independent translation initiation.
  • They are found in various eukaryotic and viral messenger RNAs (mRNAs).
  • The diversity and number of known IRES sequences are continuously expanding.

Purpose of the Study:

  • To create a comprehensive, searchable, and updated WWW resource for Internal Ribosome Entry Sites (IRES).
  • To provide detailed information and RNA sequences for known IRES elements.
  • To facilitate research on IRES function, regulation, and discovery.

Main Methods:

  • Compilation of IRES RNA sequences from public databases.
  • Development of a searchable web interface for data access.

Related Experiment Videos

  • Classification of IRES data by viral taxon, gene product function, cellular regulation, and trans-acting factors.
  • Sequences provided in FASTA format, linked to NCBI GenBank.

    • Main Results:

    • A comprehensive database of IRES sequences has been established.
    • The database is searchable and periodically updated.
    • Data is categorized for various research needs, including viral and cellular IRES.

    Conclusions:

    • The IRES database serves as a valuable resource for researchers studying translation and gene regulation.
    • It aids in the identification and characterization of novel IRES sequences.
    • The database supports ongoing research into the diverse roles of IRES elements in biology.