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Synthesis and DNA strand breakage activity of some 1,4-diazepines
Nobuko Mibu1, Miho Yukawa, Nobuhiro Kashige
1Faculty of Pharmaceutical Sciences, Fukuoka University, Fukuoka, Japan. mibu@fukuoka-u.ac.jp
Chemical & Pharmaceutical Bulletin
|January 10, 2003
Abstract:
Reactions of 1,3-propanediamine with alpha-dicarbonyl compounds (1a-e) were examined and various condensed heterocyclic compounds such as 1,4-diazepines (2) and 3-pyrimidine derivatives (3) were obtained. Some of 1,4-diazepines (2) showed DNA strand breakage activity.