Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Immunotherapy in autoimmune diseases.

K Y Fong1

  • 1Rheumatology Division, Department of Medicine, National University Hospital, 5 Lower Kent Ridge Road, Singapore 119074.

Annals of the Academy of Medicine, Singapore
|January 11, 2003
PubMed
Summary

This review explores immunotherapies for autoimmune diseases like Type I diabetes, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus. Promising treatments include tolerance induction, anti-integrin therapies, anti-cytokine agents, and B cell depletion.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Immune checkpoint inhibitors in advanced gastroesophageal adenocarcinoma: a series of patient-level meta-analyses in different programmed death-ligand 1 subgroups.

ESMO open·2024
Same author

Impact of COVID-19 on environmental services workers in healthcare settings: a scoping review.

The Journal of hospital infection·2022
Same author

Failure of sterilization in a dental outpatient facility: Investigation, risk assessment, and management.

Medicine·2022
Same author

The effect of comorbidity on hospital mortality in patients with SLE from an Asian tertiary hospital.

Lupus·2014
Same author

HLA-DQ A1, -DQB1 and -DRB1 gene polymorphism--in Malay type 1 diabetes mellitus patients and their use for risk prediction.

The Medical journal of Malaysia·2011
Same author

Neuropsychiatric lupus: clinical challenges, brain-reactive autoantibodies and treatment strategies.

Lupus·2010

Area of Science:

  • Immunology
  • Autoimmune Diseases
  • Therapeutics

Background:

  • Immunotherapy can re-balance the immune system for autoimmune condition management.
  • Autoimmune diseases affect millions globally, necessitating effective treatments.

Purpose of the Study:

  • To review clinically useful immunotherapies for autoimmune conditions.
  • Focus on Type I diabetes mellitus, multiple sclerosis, rheumatoid arthritis, and systemic lupus erythematosus.

Main Methods:

  • Medline search (1992-2002) for "immunotherapy AND autoimmune" and specific disease keywords.
  • Review of full-length articles and relevant cited publications.

Main Results:

  • Type I diabetes: Focus on tolerance induction to beta cell antigens.
  • Multiple sclerosis: Promising results with anti-alpha 4 integrins and altered peptide ligands.
  • Rheumatoid arthritis: Anti-cytokine therapy (anti-TNF alpha, IL-1Ra) improved refractory disease.
  • Systemic lupus erythematosus: Anti-CD20 antibody and stem cell transplants show potential.

Conclusions:

  • Advances in understanding autoimmune diseases and humanized monoclonal antibodies promise improved future immunotherapies.
  • Current immunotherapies offer improved quality of life and novel treatment modalities for various autoimmune conditions.

Related Experiment Videos