Platinum compounds and therapy related acute promyelocytic leukemia

Therapy related acute promyelocytic leukemia (ta-APL) is a rare complication of chemotherapy for other malignant tumors. We report two such cases, one of whom was exposed only to carboplatin two years before developing ta-APL and the other one was treated with cisplatin, etoposide and bleomycin five years prior to developing ta-APL.