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Summary
Mice can be infected with Torque teno virus (TTV). Viral DNA was detected in mouse blood and organs up to 80 days post-infection, demonstrating TTV
Area of Science:
- Virology
- Infectious Diseases
Context:
- Human blood sera containing Torque teno virus (TTV) DNA were used.
- Intravenous administration was employed for inoculation.
Purpose:
- To investigate the susceptibility of mice to TTV infection.
- To determine the dissemination and persistence of TTV in mice.
Summary:
- Viral DNA was detected in mouse blood serum, liver, and kidneys.
- TTV DNA was identified 20 days post-infection and persisted for up to 80 days in most animals.
- Polymerase chain reaction (PCR) was used to detect viral nucleotide sequences.
Impact:
- Establishes a potential animal model for studying TTV infection.
- Provides evidence for the possibility of TTV infection in mice.
- Suggests further research into TTV pathogenesis and transmission in mammalian models.