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Changes in kidney and liver function after methoxyflurane (penthrane) anaesthesia
British Journal of Anaesthesia
|February 1, 1976
Summary
Methoxyflurane anesthesia may cause transient kidney and liver dysfunction in patients. This study found impaired kidney and liver function even at doses previously considered safe, highlighting potential toxicity risks.
Area of Science:
- Anesthesiology
- Pharmacology
- Toxicology
Background:
- Methoxyflurane, halothane, and pethidine are anesthetic agents.
- Thiopentone and suxamethonium are used for induction.
- Previous understanding suggested low-dose methoxyflurane was safe.
Purpose of the Study:
- To compare the effects of methoxyflurane, halothane, and pethidine on kidney and liver function.
- To investigate potential toxicity of methoxyflurane at doses below 16 ml.
Main Methods:
- Three patient groups received different anesthetic agents post-induction.
- Multivariate Student t tests with simultaneous confidence intervals were employed.
- Kidney function markers (uric acid, creatinine, BUN, sodium) and liver function markers (SGPT, SGOT, alkaline phosphatase, bilirubin) were analyzed.
Main Results:
- Methoxyflurane group showed significant differences in kidney function markers compared to other groups.
- Methoxyflurane group also exhibited significant differences in liver function markers.
- These effects were observed at methoxyflurane doses under 16 ml.
Conclusions:
- Methoxyflurane anesthesia can lead to transient kidney and liver impairment.
- Doses of methoxyflurane below 16 ml may possess toxic effects.
- Clinical practice should consider these potential adverse effects of methoxyflurane.